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Meta gene set enrichment analyses link miR-137-regulated pathways with schizophrenia risk.

Author(s): Carrie Wright, Vince D Calhoun, Stefan Ehrlich, Lei Wang, Jessica A Turner, Nora I Perrone- Bizzozero

Publication date: 2015

Journal: Frontiers in Genetics

Publisher: Frontiers Media S.A.

Keywords: schizophrenia, microRNA, miR-137, pathway analysis, gene set enrichment analysis (GSEA), PKA signaling

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Abstract

A single nucleotide polymorphism (SNP) within MIR137, the host gene for miR-137, has been identified repeatedly as a risk factor for schizophrenia. Previous genetic pathway analyses suggest that potential targets of this microRNA (miRNA) are also highly enriched in schizophrenia-relevant biological pathways, including those involved in nervous system development and function.

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PubMed ID:: 25941532

PMC ID:: 4403556

DOI:: 10.3389/fgene.2015.00147

Keywords: schizophrenia,microRNA,miR-137,pathway analysis,gene set enrichment analysis (GSEA),PKA signaling

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Keywords: schizophrenia, microRNA, miR-137, pathway analysis, gene set enrichment analysis (GSEA), PKA signaling

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