Prognostic Value of Tubulointerstitial Lesions, Urinary N-Acetyl-β-d-Glucosaminidase, and Urinary β2-Microglobulin in Patients with Type 2 Diabetes and Biopsy-Proven Diabetic Nephropathy.

Mise, Koki; Hoshino, Junichi; Ueno, Toshiharu; Hazue, Ryo; Hasegawa, Jumpei; Sekine, Akinari; Sumida, Keiichi; Hiramatsu, Rikako; Hasegawa, Eiko; Yamanouchi, Masayuki; Hayami, Noriko; Suwabe, Tatsuya; Sawa, Naoki; Fujii, Takeshi; Hara, Shigeko; Ohashi, Kenichi; Takaichi, Kenmei; Ubara, Yoshifumi

doi:10.2215/CJN.04980515

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Prognostic Value of Tubulointerstitial Lesions, Urinary N-Acetyl-β-d-Glucosaminidase, and Urinary β2-Microglobulin in Patients with Type 2 Diabetes and Biopsy-Proven Diabetic Nephropathy.

Author(s): Koki Mise ¹ , Junichi Hoshino ² , Toshiharu Ueno ² , Ryo Hazue ² , Jumpei Hasegawa ² , Akinari Sekine ² , Keiichi Sumida ² , Rikako Hiramatsu ² , Eiko Hasegawa ² , Masayuki Yamanouchi ² , Noriko Hayami ² , Tatsuya Suwabe ² , Naoki Sawa ² , Takeshi Fujii ³ , Shigeko Hara ⁴ , Kenichi Ohashi ⁵ , Kenmei Takaichi ⁴ , Yoshifumi Ubara ⁴

Publication date (Electronic): Apr 7 2016

Journal: Clinical journal of the American Society of Nephrology : CJASN

Keywords: diabetes mellitus, type 2, diabetic nephropathy, disease progression, follow-up studies, humans, kidney failure, chronic, renal pathology, renal prognosis, tubulointerstitial lesion, urinary biomarker

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Abstract

Some biomarkers of renal tubular injury are reported to be useful for predicting renal prognosis in the early stage of diabetic nephropathy (DN). Our study compared predictions of the renal prognosis by such biomarkers and by histologic tubulointerstitial damage.

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Journal ID (iso-abbrev): Clin J Am Soc Nephrol

Title: Clinical journal of the American Society of Nephrology : CJASN

ISSN (Electronic): 1555-905X

ISSN (Print): 1555-9041

Publication date (Electronic): Apr 7 2016

Volume: 11

Issue: 4

Affiliations

[1 ] Nephrology Center, Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan; Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences; and kokims-frz@umin.ac.jp jhoshino-ind@umin.ac.jp.

[2 ] Nephrology Center.

[3 ] Department of Pathology, and.

[4 ] Nephrology Center, Okinaka Memorial Institute for Medical Research, Toranomon Hospital, Tokyo, Japan;

[5 ] Department of Pathology, and Department of Pathology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.

Article

Publisher Item ID: CJN.04980515

DOI: 10.2215/CJN.04980515

PMC ID: 4822660

PubMed ID: 26801478

SO-VID: 7fdcd67e-e3ec-4212-8a41-9b3a88588e3b

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Keywords: diabetes mellitus, type 2,diabetic nephropathy,disease progression,follow-up studies,humans,kidney failure, chronic,renal pathology,renal prognosis,tubulointerstitial lesion,urinary biomarker

Prognostic Value of Tubulointerstitial Lesions, Urinary N-Acetyl-β-d-Glucosaminidase, and Urinary β2-Microglobulin in Patients with Type 2 Diabetes and Biopsy-Proven Diabetic Nephropathy.

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