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      Effect of gentamicin and levels of ambient sound on hearing screening outcomes in the neonatal intensive care unit: A pilot study.

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          Abstract

          Hearing loss rates in infants admitted to neonatal intensive care units (NICU) run at 2-15%, compared to 0.3% in full-term births. The etiology of this difference remains poorly understood. We examined whether the level of ambient sound and/or cumulative gentamicin (an aminoglycoside) exposure affect NICU hearing screening results, as either exposure can cause acquired, permanent hearing loss. We hypothesized that higher levels of ambient sound in the NICU, and/or gentamicin dosing, increase the risk of referral on the distortion product otoacoustic emission (DPOAE) assessments and/or automated auditory brainstem response (AABR) screens.

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          Author and article information

          Journal
          Int. J. Pediatr. Otorhinolaryngol.
          International journal of pediatric otorhinolaryngology
          Elsevier BV
          1872-8464
          0165-5876
          Jun 2017
          : 97
          Affiliations
          [1 ] Department of Otolaryngology, Oregon Health & Science University, Portland, OR, United States; VA RR&D National Center for Rehabilitative Auditory Research (NCRAR), VA Portland Health Care System, Portland, Oregon, United States.
          [2 ] Department of Otolaryngology, Oregon Health & Science University, Portland, OR, United States.
          [3 ] School of Medicine, Oregon Health & Science University, Portland, OR, United States; Oregon Hearing Research Center, Oregon Health & Science University, Portland, OR, United States.
          [4 ] Oregon Hearing Research Center, Oregon Health & Science University, Portland, OR, United States.
          [5 ] Oregon Clinical and Translational Research Institute, Oregon Health & Science University, Portland, OR, United States.
          [6 ] School of Medicine, Oregon Health & Science University, Portland, OR, United States.
          [7 ] Child Development and Research Center, Oregon Health & Science University, Portland, OR, United States.
          [8 ] Department of Neonatology, Oregon Health & Science University, Portland, OR, United States.
          [9 ] Department of Otolaryngology, Oregon Health & Science University, Portland, OR, United States; Oregon Hearing Research Center, Oregon Health & Science University, Portland, OR, United States; VA RR&D National Center for Rehabilitative Auditory Research (NCRAR), VA Portland Health Care System, Portland, Oregon, United States. Electronic address: steygerp@ohsu.edu.
          Article
          S0165-5876(17)30116-7 NIHMS864852
          10.1016/j.ijporl.2017.03.025
          5439527
          28483249
          18f83e75-d3ad-46ba-8693-dd29a0aec529
          History

          Ambient sound level,Aminoglycosides,Critical care,Gentamicin,Hearing loss,Neonatal intensive care,Neonate,Newborn hearing screen,Noise,Sound pressure levels

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