43
views
0
recommends
+1 Recommend
1 collections
    1
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Roles of integrin in tumor development and the target inhibitors

      Read this article at

      ScienceOpenPublisher
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Integrin is a large family of cell adhesion molecules (CAMs) which involves in the interaction of cells/cells and cells/ extracellular matrix (ECM) to mediate cell proliferation, differentiation, adhesion, migration, etc. In recent years, aberrant expression of integrin has been clearly found in many tumor studies, indicating that integrin is closely related to tumor formation and development. Meanwhile, it has effects on tumor cell differentiation, cell migration, proliferation and tumor neovascularization. The study of drugs targeting integrins is of great significance for the clinical treatment of tumors. Because of its important role in tumorigenesis and development, integrin has become a promising target for the treatment of cancer. This review summarizes the role of integrin in tumor development and the current state of integrin inhibitors to provide a valuable reference for subsequent research.

          Related collections

          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 April 2019
          : 17
          : 4
          : 241-251
          Affiliations
          1 State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China
          Author notes
          *Corresponding author: ZHAO Li, Tel/Fax: 86-25-83271055, E-mail: zhaoli@ 123456cpu.edu.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30028-7
          10.1016/S1875-5364(19)30028-7
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81773774
          Award ID: 81473231
          Award ID: 81830105
          Funded by: Science Foundation for Distinguished Young Scholars of Jiangsu Provience
          Award ID: BK20150028
          This work was supported by the National Natural Science Foundation of China (Nos. 81773774, 81473231, 81830105), Science Foundation for Distinguished Young Scholars of Jiangsu Provience (BK20150028).

          Comments

          Comment on this article