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      Pharmacodynamic profile of carvedilol.

      Radiology

      pharmacology, Vasodilator Agents, therapeutic use, chemistry, Propanolamines, drug therapy, Hypertension, Humans, drug effects, Hemodynamics, Free Radical Scavengers, Carbazoles, Animals, Adrenergic beta-Antagonists, Adrenergic alpha-Antagonists

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          Abstract

          The combination of a beta blocker and a vasodilator is logical in the treatment of high blood pressure. Systemic arteriolar dilatation is beneficial to reduce the elevated peripheral resistance and hence to decrease cardiac afterload. beta-Adrenoceptor blockade exerts its own antihypertensive activity and also suppresses the reflex tachycardia induced by vasodilation. The combined beta- and alpha-adrenoceptor blockade exerted by carvedilol imposes these beneficial hemodynamic effects. Carvedilol is a nonselective beta-adrenoceptor antagonist, devoid of intrinsic sympathomimetic activity and possessing selective alpha 1-adrenoceptor-blocking activity, although this is considerably weaker than its beta-adrenoceptor antagonistic activity. One isomer [S(-)-carvedilol] contains both the beta- and alpha-adrenoceptor activity, whereas R(+)-carvedilol is only a weak alpha blocker. Carvedilol is produced as the racemate. The hemodynamic profile is in accordance with that to be expected from the combination of beta and alpha blockade.

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          8106159

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