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      Clonal interference and the evolution of RNA viruses.

      Science (New York, N.Y.)
      Adaptation, Physiological, Animals, Biological Evolution, Cell Line, Confidence Intervals, Cricetinae, Gene Frequency, Genes, Viral, Likelihood Functions, Models, Biological, Models, Statistical, Mutation, Vesicular stomatitis Indiana virus, genetics, physiology, Virus Replication

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          Abstract

          In asexual populations, beneficial mutations that occur in different lineages compete with one another. This phenomenon, known as clonal interference, ensures that those beneficial mutations that do achieve fixation are of large effect. Clonal interference also increases the time between fixations, thereby slowing the adaptation of asexual populations. The effects of clonal interference were measured in the asexual RNA virus vesicular stomatitis virus; rates and average effects of beneficial mutations were quantified.

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