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      Detection of SARS-CoV-2 in Different Types of Clinical Specimens

      research-article
      , PhD 1 , , MD 2 , , MD 3 , , MPH 1 , , BS 2 , , MD 1 , , MD, PhD 1 ,
      JAMA
      American Medical Association

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          Abstract

          This study describes results of PCR and viral RNA testing for SARS-CoV-2 in bronchoalveolar fluid, sputum, feces, blood, and urine specimens from patients with COVID-19 infection in China to identify possible means of non-respiratory transmission.

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          Author and article information

          Journal
          JAMA
          JAMA
          JAMA
          JAMA
          American Medical Association
          0098-7484
          1538-3598
          12 May 2020
          11 March 2020
          11 March 2020
          : 323
          : 18
          : 1843-1844
          Affiliations
          [1 ]National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China
          [2 ]Beijing Ditan Hospital, Capital Medical University, Beijing, China
          [3 ]Qingdao Municipal Center for Disease Control and Prevention, Qingdao, China
          Author notes
          Article Information
          Accepted for Publication: March 5, 2020.
          Corresponding Author: Wenjie Tan, MD, PhD, National Institute for Viral Disease Control and Prevention, China CDC, 155 Changbai Rd, Changping District, Beijing 102206, China ( tanwj@ 123456ivdc.chinacdc.cn ).
          Published Online: March 11, 2020. doi:10.1001/jama.2020.3786
          Author Contributions: Drs Wang and Tan had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Drs Wang and Xu contributed equally.
          Concept and design: Wang, Xu, Wu, Tan.
          Acquisition, analysis, or interpretation of data: Xu, Gao, Lu, Han, Tan.
          Drafting of the manuscript: Wang, Xu, Gao, Han, Tan.
          Critical revision of the manuscript for important intellectual content: Xu, Lu, Wu, Tan.
          Statistical analysis: Wang.
          Obtained funding: Wang, Tan.
          Administrative, technical, or material support: Xu, Gao, Lu, Han, Wu.
          Supervision: Xu, Wu, Tan.
          Conflict of Interest Disclosures: None reported.
          Funding/Support: This work was supported by grants 2016YFD0500301 and 2020YFC0840900 from the National Key Research and Development Program of China and 2018ZX10101002 from the National Major Project for Control and Prevention of Infectious Disease in China.
          Role of the Funder/Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
          Additional Contributions: We thank Gary Wong, PhD (CAS Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China) for English revision of the manuscript, and clinical staff members in hospitals in Hubei Province, Shandong Province, and Beijing for collection of specimens. None of these individuals received compensation for their contributions.
          Article
          PMC7066521 PMC7066521 7066521 jld200018
          10.1001/jama.2020.3786
          7066521
          32159775
          14784b85-b28d-4513-9e6a-d91c0a205b14
          Copyright 2020 American Medical Association. All Rights Reserved.
          History
          : 17 February 2020
          : 5 March 2020
          Categories
          Letter
          Letters
          Research Letter
          Online First

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