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      MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset.

      The New England journal of medicine
      Massachusetts Medical Society

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          Abstract

          Under current guidelines, intravenous thrombolysis is used to treat acute stroke only if it can be ascertained that the time since the onset of symptoms was less than 4.5 hours. We sought to determine whether patients with stroke with an unknown time of onset and features suggesting recent cerebral infarction on magnetic resonance imaging (MRI) would benefit from thrombolysis with the use of intravenous alteplase.

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          Journal
          29766770
          10.1056/NEJMoa1804355

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