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P2Y12 receptor-mediated activation of spinal microglia and p38MAPK pathway contribute to cancer-induced bone pain.

Author(s): Mingjuan Liu, Ming Yao, Hanqi Wang, Longsheng Xu, Ying Zheng, Bing Huang, Huadong Ni, Shijie Xu, Xuyan Zhou, Qingquan Lian

Publication date: 2017

Journal: Journal of Pain Research

Publisher: Informa UK Ltd.

Keywords: p38MAPK pathway, cancer-induced bone pain, P2Y12 receptor, cytokines

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Abstract

Cancer-induced bone pain (CIBP) is one of the most challenging clinical problems due to a lack of understanding the mechanisms. Recent evidence has demonstrated that activation of microglial G-protein-coupled P2Y12 receptor (P2Y12R) and proinflammatory cytokine production play an important role in neuropathic pain generation and maintenance. However, whether P2Y12R is involved in CIBP remains unknown.

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PubMed ID:: 28243146

PMC ID:: 5317303

DOI:: 10.2147/JPR.S124326

Keywords: p38MAPK pathway,cancer-induced bone pain,P2Y12 receptor,cytokines

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Keywords: p38MAPK pathway, cancer-induced bone pain, P2Y12 receptor, cytokines

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