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      International Journal of COPD (submit here)

      This international, peer-reviewed Open Access journal by Dove Medical Press focuses on pathophysiological processes underlying Chronic Obstructive Pulmonary Disease (COPD) interventions, patient focused education, and self-management protocols. Sign up for email alerts here.

      39,063 Monthly downloads/views I 2.893 Impact Factor I 5.2 CiteScore I 1.16 Source Normalized Impact per Paper (SNIP) I 0.804 Scimago Journal & Country Rank (SJR)

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      Reticular basement membrane in asthma and COPD: Similar thickness, yet different composition

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          Abstract

          Background

          Reticular basement membrane (RBM) thickening has been variably associated with asthma and chronic obstructive pulmonary disease (COPD). Even if RBM thickness is similar in both diseases, its composition might still differ.

          Objective

          To assess whether RBM thickness and composition differ between asthma and COPD.

          Methods

          We investigated 24 allergic asthmatics (forced expiratory volume in one second [FEV 1] 92% predicted), and 17 nonallergic COPD patients (FEV 1 60% predicted), and for each group a control group of similar age and smoking habits (12 and 10 persons, respectively). Snap-frozen sections of bronchial biopsies were stained with hematoxylin/eosin and for collagen I, III, IV, V, laminin and tenascin. RBM thickening was assessed by digital image analysis. Relative staining intensity of each matrix component was determined.

          Results

          Mean (SD) RBM thickness was not significantly different between asthma and COPD 5.5 (1.3) vs 6.0 (1.8) μm, but significantly larger than in their healthy counterparts, ie, 4.7 (0.9) and 4.8 (1.2) μm, respectively. Collagen I and laminin stained significantly stronger in asthma than in COPD. Tenascin stained stronger in asthma than in healthy controls of similar age, and stronger in COPD controls than in asthma controls (p < 0.05).

          Conclusion

          RBM thickening occurs both in asthma and COPD. We provide supportive evidence that its composition differs in asthma and COPD.

          Most cited references50

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          Asthma. From bronchoconstriction to airways inflammation and remodeling.

          J. Bousquet, P K Jeffery, W Busse … (2000)
          Article 0 comments Cited 244 times – based on 0 reviews     Review now
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            Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics.

            S E Wenzel, L B Schwartz, E L Langmack … (1999)
            The mechanisms associated with the development of severe, corticosteroid (CS)-dependent asthma are poorly understood, but likely heterogenous. It was hypothesized that severe asthma could be divided pathologically into two inflammatory groups based on the presence or absence of eosinophils, and that the inflammatory subtype would be associated with distinct structural, physiologic, and clinical characteristics. Thirty-four severe, refractory CS-dependent asthmatics were evaluated with endobronchial biopsy, pulmonary function, allergy testing, and clinical history. Milder asthmatic and normal control subjects were also evaluated. Tissue cell types and subbasement membrane (SBM) thickness were evaluated immunohistochemically. Fourteen severe asthmatics [eosinophil (-)] had nearly absent eosinophils (< 2 SD from the normal mean). The remaining 20 severe asthmatics were categorized as eosinophil (+). Eosinophil (+) severe asthmatics had associated increases (p < 0.05) in lymphocytes (CD3+, CD4+, CD8+), mast cells, and macrophages. Neutrophils were increased in severe asthmatics and not different between the groups. The SBM was significantly thicker in eosinophil (+) severe asthmatics than eosinophil (-) severe asthmatics and correlated with eosinophil numbers (r = 0.50). Despite the absence of eosinophils and the thinner SBM, the FEV(1) was marginally lower in eosinophil (-) asthmatics (p = 0.05) with no difference in bronchodilator response. The eosinophil (+) group (with a thicker SBM) had more intubations than the eosinophil (-) group (p = 0.0004). Interestingly, this group also had a decreased FVC/slow vital capacity (SVC). These results suggest that two distinct pathologic, physiologic, and clinical subtypes of severe asthma exist, with implications for further research and treatment.
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              Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease. American Thoracic Society.

              GL Snider, B Tiep, J. Heffner … (1995)
              Article 0 comments Cited 156 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Int J Chron Obstruct Pulmon Dis
                Journal ID (publisher-id): International Journal of COPD
                Title: International Journal of Chronic Obstructive Pulmonary Disease
                Publisher: Dove Medical Press
                ISSN (Print): 1176-9106
                ISSN (Electronic): 1178-2005
                Publication date Collection: 2009
                Publication date (Print): 2009
                Publication date (Electronic): 15 April 2009
                Volume: 4
                Pages: 127-135
                Affiliations
                [1 ] Department of Pulmonology
                [2 ] Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
                Author notes
                Correspondence: Nick H Ten Hacken Department of Pulmonology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, PO Box 30001, 9700RB Groningen, The Netherlands, Tel +31 50 361 2357, Fax +31 50 361 9320, Email n.h.t.ten.hacken@ 123456int.umcg.nl
                Article
                Publisher ID: copd-4-127
                PMC ID: 2672795
                PubMed ID: 19436691
                SO-VID: 77e76083-d274-4198-9348-65eea55d1b02
                Copyright © © 2009 Liesker et al, publisher and licensee Dove Medical Press Ltd.
                License:

                This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

                History
                Categories
                Subject: Original Research

                ScienceOpen disciplines: Respiratory medicine
                Keywords: reticular basement membrane thickness,reticular basement membrane composition,asthma,biopsy,copd,remodeling
                Data availability:
                ScienceOpen disciplines: Respiratory medicine
                Keywords: reticular basement membrane thickness, reticular basement membrane composition, asthma, biopsy, copd, remodeling

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