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      Synthesis and evaluation of pH dependent hydrogels for controlled release of Venlafaxine HCl

      British Journal of Pharmacy
      University of Huddersfield Press

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          Abstract

          pH dependent hydrogel formulations of venlafexine HCl were prepared by free radical polymerization method using polyethylene glycol as polymer. Various samples were prepared with varying concentration of polymer, monomer and cross-linker to study their effect on gel swelling, diffusion characteristics and drug release. Swelling was found to be increased with increase in pH. Increase in acrylic acid concentration increases swelling while increase in cross-linker concentration has an opposite effect on swelling. Drug release study was performed in pH 1.2, 5.5 and 7.5for 12 hours at 37 oC and drug release was found to increase in higher pH. Prepared hydrogel preparations were also characterized by PXRD, TGA, SEM and FTIR.

          Author and article information

          Journal
          British Journal of Pharmacy
          BJPharm
          University of Huddersfield Press
          20588356
          January 12 2017
          January 12 2017
          : 2
          : 2
          Article
          10.5920/bjpharm.2017.30
          e4096f4f-103f-4fda-aecb-17eb953b753e
          © 2017

          This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

          History

          Medicine,Pharmacology & Pharmaceutical medicine,Health & Social care
          Medicine, Pharmacology & Pharmaceutical medicine, Health & Social care

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