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      Inward Remodeling Follows Chronic Vasoconstriction in Isolated Resistance Arteries

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      Journal of Vascular Research
      S. Karger AG

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          Abstract

          The hypothesis was tested that chronic vasoconstriction is followed by a structural reduction in lumen diameter, measured at full dilation. An in vitro model of pressurized rat skeletal muscle arterioles was used. During a 3-day experimental period, constriction of active vessels was achieved with fetal calf serum or endothelin-1 (ET-1). Maximal dilation revealed inward remodeling from 179 ± 6.5 µm lumen diameter on day 0 to 151 ± 6.3 µm on day 3 at 75 mm Hg in vessels incubated with serum (n = 8). Similarly, ET-1 induced inward remodeling from 182 ± 5.2 to 164 ± 3.7 µm (n = 6). When constriction during organoid culture was inhibited with papaverin or verapamil, inward remodeling was fully prevented: 184 ± 6.3 to 184 ± 5.8 µm for papaverin (n = 6) and 174 ± 5.5 to 177 ± 7.4 µm for verapamil (n = 6). A chronic reduction in diameter without tone was achieved in vessels that were kept at a low pressure (2–5 mm Hg; n = 6). Here, no remodeling was found, thereby ruling out that a chronic reduction in diameter alone is sufficient for inward remodeling. These data show that a persistent active reduction in lumen diameter is followed by inward remodeling of arterioles.

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            Author and article information

            Journal
            Journal of Vascular Research
            J Vasc Res
            S. Karger AG
            1018-1172
            1423-0135
            February 1 2002
            2002
            February 13 2002
            : 39
            : 1
            : 12-20
            Article
            10.1159/000048989
            87129e0e-f862-4b48-9de2-7f484b37e497
            © 2002

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