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      [Inhibition of the muscarinic potassium current by KB130015, a new antiarrhythmic agent to treat atrial fibrillation].

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          Abstract

          Vagus-induced atrial fibrillation is of particular clinical interest. The muscarinic potassium current I(K(ACh)) mediates the induction of vagus-induced atrial fibrillation. Selective inhibition of I(K(ACh)) seems to be an option to treat atrial fibrillation. The application of amiodarone, presently one of the most important antiarrhythmic agents in the parmacological treatment of atrial fibrillation, is limited by its adverse effects. KB130015, a new amiodarone derivative, and ibutilide are new class III antiarrhythmic agents.

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          Author and article information

          Journal
          Med. Klin. (Munich)
          Medizinische Klinik (Munich, Germany : 1983)
          Springer Science and Business Media LLC
          0723-5003
          0723-5003
          Nov 15 2005
          : 100
          : 11
          Affiliations
          [1 ] Medizinische Klinik II (Schwerpunkte Kardiologie und Angiologie), Ruhr-Universität, Bochum. rolf.borchard@ruhr-uni-bochum.de
          Article
          10.1007/s00063-005-1096-z
          16328176
          af76932d-92ad-4f6f-99bb-00dccbb62491

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