IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function.

Rivas, Magali Noval; Burton, Oliver T.; Oettgen, Hans C.; Chatila, Talal

doi:10.1016/j.jaci.2016.02.030

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IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function.

Author(s): Magali Noval Rivas ¹ , Oliver T Burton ¹ , Hans C Oettgen ¹ , Talal Chatila ²

Publication date (Electronic): Sep 2016

Journal: The Journal of allergy and clinical immunology

Keywords: Anaphylaxis, IL-13, IL-33, IL-4, food allergy, group 2 innate lymphoid cells, innate lymphoid cells, mast cells, nuocytes, oral tolerance, regulatory T cells

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Abstract

Food allergy is a major health issue, but its pathogenesis remains obscure. Group 2 innate lymphoid cells (ILC2s) promote allergic inflammation. However their role in food allergy is largely unknown.

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Journal ID (iso-abbrev): J. Allergy Clin. Immunol.

Title: The Journal of allergy and clinical immunology

ISSN (Electronic): 1097-6825

ISSN (Print): 0091-6749

Publication date (Electronic): Sep 2016

Volume: 138

Issue: 3

Affiliations

[1 ] Division of Immunology, Boston Children's Hospital, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass.

[2 ] Division of Immunology, Boston Children's Hospital, Boston, Mass; Department of Pediatrics, Harvard Medical School, Boston, Mass. Electronic address: talal.chatila@childrens.harvard.edu.

Article

Publisher Item ID: S0091-6749(16)30083-5 Mid ID: NIHMS779517

DOI: 10.1016/j.jaci.2016.02.030

PMC ID: 5014699

PubMed ID: 27177780

SO-VID: 814ccb27-d7b1-4e2b-88da-2effe178a501

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Keywords: Anaphylaxis,IL-13,IL-33,IL-4,food allergy,group 2 innate lymphoid cells,innate lymphoid cells,mast cells,nuocytes,oral tolerance,regulatory T cells

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Keywords: Anaphylaxis, IL-13, IL-33, IL-4, food allergy, group 2 innate lymphoid cells, innate lymphoid cells, mast cells, nuocytes, oral tolerance, regulatory T cells

IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function.

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Abstract

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Regulatory T cell (Treg) therapy

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