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      Signal Transduction Mechanisms Mediating the Vascular Actions of Endothelin

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      Journal of Vascular Research
      S. Karger AG

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          Abstract

          Endothelin (ET)-1 an endothelium-derived vasoactive polypeptide encoded in the human genome, is the most potent vasoconstrictor identified to date. In addition to its acute role in modulating vascular smooth muscle tone, ET-1 also plays a critical role in the long-term control of cellular growth within the vasculature and thus, modulates the chronic remodeling of the vascular tree. In order to produce such a diverse range of biological responses, this peptide is able to activate numerous distinct effector systems including phospholipase C, phospholipase D, phospholipase A<sub>2</sub>, adenylate and guanylate cyclases and numerous cytosolic/nuclear protein kinases. These actions, mediated via an interaction with two major subtypes of cell surface seven-transmembrane receptors (ET<sub>a</sub> and ET<sub>B</sub>), are coupled to their effector systems by several distinct types of guanine nucleotide regulatory proteins (both inhibitory and stimulatory G proteins). This review describes such intercations and how distinct pharmacological agents have been used to identify the diverse signaling mechanisms utilized by the ET isopeptides.

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          Author and article information

          Journal
          Journal of Vascular Research
          J Vasc Res
          S. Karger AG
          1423-0135
          1018-1172
          1997
          1997
          : 34
          : 3
          : 152-164
          Article
          10.1159/000159219
          68d246a9-5991-42b1-834f-41df093e2c3d
          © 1997
          History

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