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      Synthesis and evaluation of pH dependent hydrogels for controlled release of venlafaxine HCl

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          Summary

          pH dependent hydrogel formulations of venlafexine HCl were prepared by free radical polymerization method using polyethylene glycol as polymer. Various samples were prepared with varying concentration of polymer, monomer and cross-linker to study their effect on gel swelling, diffusion characteristics and drug release. Swelling was found to be increased with increase in pH. Increase in acrylic acid concentration increases swelling while increase in cross-linker concentration has an opposite effect on swelling. Drug release study was performed in pH 1.2, 5.5 and 7.5 for 12 hours at 37 °C and drug release was found to increase in higher pH. Prepared hydrogel preparations were also characterized by PXRD, TGA, SEM and FTIR.

          Author and article information

          Journal
          BJPharm
          British Journal of Pharmacy
          University of Huddersfield Press
          2058-8356
          11 July 2018
          : 2
          : 2 , Proceedings of the 8 th APS International PharmSci 2017
          : S43-S44
          Affiliations
          [a ]University College of Pharmacy, University of the Punjab, Lahore, Pakistan
          [b ]Akson College of Pharmacy, Mirpur, AJ &K, Pakistan
          Author notes
          *Corresponding author. Tel.: +92 42 99211616 Fax: +92 42 99211616 E-mail: nadeem_irfan@ 123456hotmail.com nasirabbas77@ 123456gmail.com
          Article
          10.5920/bjpharm.2017.30
          e4096f4f-103f-4fda-aecb-17eb953b753e
          © 2017, Nasir Abbas, Qazi Amir Ijaz, Amjad Hussain, Nadeem Irfan Bukhari

          This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0 https://creativecommons.org/licenses/by/4.0/.

          History
          : 00 00 2017
          : 00 00 2017

          Medicine,Pharmacology & Pharmaceutical medicine,Health & Social care
          hydrogel,polyethylene glycol,controlled release,Venlafexine

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