Involvement of mitochondrial apoptotic pathway and MAPKs/NF-κ B inflammatory pathway in the neuroprotective effect of atractylenolide III in corticosterone-induced PC12 cells
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Atractylenolide III (ATL-III), a sesquiterpene compound isolated from Rhizoma Atractylodis
Macrocephalae , has revealed a number of pharmacological properties including anti-inflammatory,
anti-cancer activity, and neuroprotective effect. This study aimed to evaluate the
cytoprotective efficiency and potential mechanisms of ATL-III on corticosterone injured
rat phaeochromo-cytoma (PC12) cells. Our results demonstrate that ATL-III increases
cell viability and reduces the release of lactate dehydrogenase (LDH). The results
suggest that ATL-III protects PC12 cells from corticosterone-induced injury by inhibiting
the intracellular Ca 2+ overloading, inhibiting the mitochondrial apoptotic pathway
and modulating the MAPK/NF- κ B inflammatory pathways. These findings provide a novel
insight into the molecular mechanism by which ATL-III protected the PC12 cells against
corticosterone-induced injury for the first time. Our results provide the evidence
that ATL-III may serve as a therapeutic agent in the treatment of depression.
Author and article information
Journal
Title:
Chinese Journal of Natural Medicines
Abbreviated Title:
Chinese Journal of Natural Medicines