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      • Article: found

      Effects of chymase on the macular region in monkeys and porcine muller cells: probable involvement of chymase in the onset of idiopathic macular holes.

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          Abstract

          To investigate chymase involvement in idiopathic macular hole onset, the effects of chymase on monkey eyes and cultured Muller cells were investigated.

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          Most cited references17

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          CNS stem cells express a new class of intermediate filament protein.

          Urban Lendahl, Lyle Zimmerman, Ronald D.G. McKay (1990)
          Multipotential CNS stem cells receive and implement instructions governing differentiation to diverse neuronal and glial fates. Exploration of the mechanisms generating the many cell types of the brain depends crucially on markers identifying the stem cell state. We describe a gene whose expression distinguishes the stem cells from the more differentiated cells in the neural tube. This gene was named nestin because it is specifically expressed in neuroepithelial stem cells. The predicted amino acid sequence of the nestin gene product shows that nestin defines a distinct sixth class of intermediate filament protein. These observations extend a model in which transitions in intermediate filament gene expression reflect major steps in the pathway of neural differentiation.
          Article 0 comments Cited 470 times – based on 0 reviews     Review now
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            Retinal stem cells in the adult mammalian eye.

            V Tropepe, B L Coles, B Chiasson … (2000)
            The mature mammalian retina is thought to lack regenerative capacity. Here, we report the identification of a stem cell in the adult mouse eye, which represents a possible substrate for retinal regeneration. Single pigmented ciliary margin cells clonally proliferate in vitro to form sphere colonies of cells that can differentiate into retinal-specific cell types, including rod photoreceptors, bipolar neurons, and Müller glia. Adult retinal stem cells are localized to the pigmented ciliary margin and not to the central and peripheral retinal pigmented epithelium, indicating that these cells may be homologous to those found in the eye germinal zone of other nonmammalian vertebrates.
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              Müller glia are a potential source of neural regeneration in the postnatal chicken retina.

              Thomas Reh, William A. Fischer (2001)
              The retina of warm-blooded vertebrates is believed to be incapable of neural regeneration. Here we provide evidence that the retina of postnatal chickens has the potential to generate new neurons. In response to acute damage, numerous Müller glia re-entered the cell cycle, and shortly thereafter, expressed CASH-1, Pax6 and Chx10, transcription factors expressed by embryonic retinal progenitors. These progenitor-like cells transiently expressed neurofilament. Newly formed cells became distributed throughout the inner and outer nuclear layers of the retina, and remained for at least three weeks after damage. Some of these newly formed cells differentiated into retinal neurons, a few formed Müller glia, and most remained undifferentiated, with continued expression of Pax6 and Chx10. These cells continued to proliferate when grown in culture, with some differentiating into retinal neurons or Müller glia. We propose that, in response to damage, Müller glia in the retina are a potential source of neural regeneration.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Ophthalmic Res.
                Title: Ophthalmic research
                Publisher: S. Karger AG
                ISSN: 0030-3747
                ISSN (Print): 0030-3747
                Publication date (Electronic): 2006
                Volume: 38
                Issue: 4
                Affiliations
                [1 ] Department of Ophthalmology, Osaka Medical College, 27 Daigaku-cho, Takatsuki, Osaka 569-8686, Japan. opt17@poh.osaka-med.ac.jp
                Article
                Publisher Item ID: 93072
                DOI: 10.1159/000093072
                PubMed ID: 16679808
                SO-VID: fd375db8-7cd5-4ebb-9ba0-abc48e0dfea9
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