Between 1991 and 2001, there was a 20% increase in the number of Canadian children under 18 years old who were living with their grandparents without a parent present in the home. Recent research revealed that Canadians of First Nations origin, including North American Indians, Métis, and Inuit, were vastly over-represented among grandparents raising grandchildren in skipped generation households (households which include only grandparents and grandchildren). Using custom tabulation data from the 1996 Canadian Census, this article presents a profile of First Nations Canadian grandparents raising grandchildren in skipped generation households. Despite extremely high rates of poverty and disability, one-third of First Nations Canadian skipped generation families were raising two or more grandchildren. In comparison to other grandparent caregivers, First Nations custodial caregivers were more likely to also be caring for a senior (23%) and to spend more than 30 hours a week on childcare duties (46%) and on housework (41%). Implications for policy, practice, and research are discussed.