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Abstract
The probiotic Akkermansia muciniphila ( A. muciniphila ) is an intestinal bacterium
that was first identified in human feces in 2004. Its specialization in mucin degradation
makes it a key microorganism that maintains intestinal mucosal barrier function. As
an unique representative strain of the phylum Verrucomicrobia that can be cultured
in vitro , A. muciniphila is much easier to detect by metagenomic analysis of intestinal
flora. In the past few years, A. muciniphila has been getting increasing attention
for the positive correlation between its intestinal colonization and host homeostatic
metabolism. In this review, we summarize the relationship between A. muciniphila
and host health and diseases, especially focusing on metabolic diseases and related
mechanisms, as well as the natural food and drug-derived substrates affecting its
colonization in the host, expecting to provide evidence and clues for the development
of drugs targeting A. muciniphila .
Author and article information
Journal
Title:
Chinese Journal of Natural Medicines
Abbreviated Title:
Chinese Journal of Natural Medicines