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      Aquaporin 3 promotes epithelial-mesenchymal transition in gastric cancer.

      Journal of Experimental & Clinical Cancer Research : CR
      Springer Science and Business Media LLC

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          Abstract

          Gastric carcinoma (GC) is a common and lethal malignancy, and epithelial-mesenchymal transition (EMT) is believed to contribute to invasive and metastatic tumor growth. Aquaporin 3 (AQP3) is overexpressed in human GC tissues, while human epidermal growth factor (EGF) and hepatocyte growth factor, which can induce EMT, are able to up-regulate AQP3 expression, subsequently promoting GC cell migration and proliferation. The purpose of this study was to investigate the effects of AQP3 on EMT in human GC.

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          Journal
          24887009
          4036310
          10.1186/1756-9966-33-38

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