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      Structural changes in the renal proximal tubular cells induced by iodinated contrast media.

      1 , , , ,
      Nephron
      S. Karger AG

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          Abstract

          The renal morphologic changes induced by intravenously injected contrast media (CMs) were studied in 40 Wistar rats which had been deprived of water 24 h before the CM injection. In the first part of the investigation, the kidneys were fixed by perfusion for light and electron microscopy 2 h after injection of 3 g iodine/kg of iopamidol, iobitridol or iohexol. Control animals received physiologic saline. In the second part of the study, the fixation was performed 48 h after the injection of the corresponding dose of iobitridol or iohexol. The structural changes were semiquantitatively evaluated by two independent observers unaware of the agent injected. The lysosomes of the proximal convoluted tubular cells showed moderate changes 2 h after the iopamidol injection. Iobitridol and iohexol induced prominent lysosomal alterations with signs of cytoplasmic injury. After 48 h, the changes induced by iobitridol had almost disappeared, whereas the iohexol group still showed a statistically significant vacuolization. Although the general physicochemical properties of iobitridol and iohexol appear similar in vitro, the different lysosomal alteration might reflect differences in their characteristics in vivo.

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          Author and article information

          Journal
          Nephron
          Nephron
          S. Karger AG
          1660-8151
          1660-8151
          1997
          : 76
          : 1
          Affiliations
          [1 ] Department of Diagnostic Radiology, Helsinki University Central Hospital, Finland.
          Article
          10.1159/000190147
          9171307
          af34fd62-86e6-4835-8666-eca6ecd968ad
          History

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