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Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
February 2017
February 2017
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Abstract
Cancer immunotherapy can induce long lasting responses in patients with metastatic
cancers of a wide range of histologies. Broadening the clinical applicability of these
treatments requires an improved understanding of the mechanisms limiting cancer immunotherapy.
The interactions between the immune system and cancer cells are continuous, dynamic,
and evolving from the initial establishment of a cancer cell to the development of
metastatic disease, which is dependent on immune evasion. As the molecular mechanisms
of resistance to immunotherapy are elucidated, actionable strategies to prevent or
treat them may be derived to improve clinical outcomes for patients.