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Erodible Film Formulation for Potential Ocular Drug Delivery

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      Drug delivery to the eye has always been an interesting and challenging field in pharmaceutical formulation and drug design. The aim of this research was the formulation development of thin erodible films for potential delivery of lopidine to treat glaucoma. Films were prepared using hyaluronic acid (HA) and hydroxypropyl methylcellulose (HPMC) as polymers, together with glycerol (GLY) as plasticiser. Single layer films were prepared using each polymer individually, as well as in combination to obtain composite thin films. Various combinations and concentrations were optimised to reach the desired transparency, which were then characterised for their physico-chemical and mechanical properties. The following ratios were selected for drug loading: 2% HPMC, 1% HA, 1% composite (HPMC 1:1 HA) and 2% composite (HPMC 1.5:0.5 HA) with all of them containing a ratio of 2:1 polymer to plasticiser.

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      Department of Pharmaceutical, Chemical and Environmental Sciences, Faculty of Engineering and Science, University of Greenwich, Medway Campus, Kent ME4 4TB, UK.
      Author notes
      *Corresponding author. Tel.: +44 2083 318 980 E-mail: j.s.boateng@
      British Journal of Pharmacy
      University of Huddersfield Press
      11 July 2018
      : 2
      : 2 , Proceedings of the 8 th APS International PharmSci 2017
      : S29-S30
      © 2017, M.A. Tighsazzadeh, J.S. Boateng

      This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0



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