Motion-corrected whole-heart PET-MR for the simultaneous visualisation of coronary artery integrity and myocardial viability: an initial clinical validation

Several self-navigation techniques have been proposed to improve respiratory motion compensation in coronary MR angiography. In this work, we implemented a 2D self-navigation method by using the startup profiles of a whole-heart balanced Steady-state free precession sequence, which are primarily used to catalyze the magnetization towards the steady-state. To create 2D self-navigation images (2DSN), we added phase encoding gradients to the startup profiles. With this approach we calculated foot-head and left-right motion and performed retrospective translational motion correction. The 2DSN images were reconstructed from 10 startup profiles acquired at the beginning of each shot. Nine healthy subjects were scanned, and the proposed method was compared to a 1D self-navigation (1DSN) method with foot-head correction only. Foot-head correction was also performed with the diaphragmatic 1D pencil beam navigator (1Dnav) using a tracking factor of 0.6. 2DSN shows improved motion correction compared to 1DSN and 1Dnav for all coronary arteries and all subjects for the investigated diaphragmatic gating window of 10 mm. The visualized vessel length of the right coronary artery could be significantly improved with a multiple targeted 2D self-navigation approach, compared to 2DSN method. Copyright © 2011 Wiley Periodicals, Inc.

To develop an efficient 3D affine respiratory motion compensation framework for Cartesian whole-heart coronary magnetic resonance angiography (MRA).