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      • Record: found
      • Abstract: found
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      Effect of genetically determined host factors on the efficacy of vidarabine, acyclovir and 5-trifluorothymidine in herpes simplex virus type 1 infection.

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      Publication date:
      Journal: Ophthalmic research
      Keywords: Acyclovir, pharmacology, Animals, Embryo, Mammalian, microbiology, Female, Fibroblasts, Genetic Variation, Herpesvirus 1, Human, drug effects, physiology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Pregnancy, Trifluridine, Vero Cells, Vidarabine, Virus Replication, genetics

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          Abstract

          The susceptibility of Herpes simplex virus (HSV) to acyclovir (ACV), 5-trifluorothymidine (TFT) and vidarabine (Ara-A) in HSV-infected embryo fibroblasts from BALB/c and C57BL/6 mice as well as Vero cells were measured. Ara-A and TFT (at its highest concentration) were more effective in Vero cells and BALB/c mouse embryo fibroblasts (MEF) than in C57BL/6 MEF. In contrast, ACV was more effective in C57BL/6 MEF than BALB/c MEF and Vero cells. These data suggest that genetically determined differences in the ability of host cells to support the replication of HSV influence the activity of antiviral drugs.

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          PubMed ID:: 8196938

          ScienceOpen disciplines: Chemistry
          Keywords: Acyclovir,pharmacology,Animals,Embryo, Mammalian,microbiology,Female,Fibroblasts,Genetic Variation,Herpesvirus 1, Human,drug effects,physiology,Mice,Mice, Inbred BALB C,Mice, Inbred C57BL,Pregnancy,Trifluridine,Vero Cells,Vidarabine,Virus Replication,genetics
          Data availability:
          ScienceOpen disciplines: Chemistry
          Keywords: Acyclovir, pharmacology, Animals, Embryo, Mammalian, microbiology, Female, Fibroblasts, Genetic Variation, Herpesvirus 1, Human, drug effects, physiology, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Pregnancy, Trifluridine, Vero Cells, Vidarabine, Virus Replication, genetics

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