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      mTOR Signaling in Growth, Metabolism, and Disease.

      Cell
      Elsevier BV
      aging, cancer, cell growth, diabetes, mTOR, mTORC1, mTORC2, metabolism, nutrients, signaling

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          Abstract

          The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors. Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated in the progression of cancer and diabetes, as well as the aging process. Here, we review recent advances in our understanding of mTOR function, regulation, and importance in mammalian physiology. We also highlight how the mTOR signaling network contributes to human disease and discuss the current and future prospects for therapeutically targeting mTOR in the clinic.

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          Author and article information

          Journal
          28283069
          5394987
          10.1016/j.cell.2017.02.004

          aging,cancer,cell growth,diabetes,mTOR,mTORC1,mTORC2,metabolism,nutrients,signaling

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