58
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Diagnosis and Management of the Antiphospholipid Syndrome.

      1 , 1
      The New England journal of medicine
      Massachusetts Medical Society

      Read this article at

      ScienceOpenPublisherPubMed
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references36

          • Record: found
          • Abstract: not found
          • Article: not found

          The pathogenesis of the antiphospholipid syndrome.

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Release of neutrophil extracellular traps by neutrophils stimulated with antiphospholipid antibodies: a newly identified mechanism of thrombosis in the antiphospholipid syndrome.

            Antiphospholipid antibodies (aPL), especially those targeting β2 -glycoprotein I (β2 GPI), are well known to activate endothelial cells, monocytes, and platelets, with prothrombotic implications. In contrast, the interaction of aPL with neutrophils has not been extensively studied. Neutrophil extracellular traps (NETs) have recently been recognized as an important activator of the coagulation cascade, as well as an integral component of arterial and venous thrombi. This study was undertaken to determine whether aPL activate neutrophils to release NETs, thereby predisposing to the arterial and venous thrombosis inherent in the antiphospholipid syndrome (APS).
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Guidelines on the investigation and management of antiphospholipid syndrome.

                Bookmark

                Author and article information

                Journal
                N. Engl. J. Med.
                The New England journal of medicine
                Massachusetts Medical Society
                1533-4406
                0028-4793
                May 24 2018
                : 378
                : 21
                Affiliations
                [1 ] From the University of Washington School of Medicine, Seattle (D.G.); and the Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, Weill Cornell Medicine, New York (D.E.).
                Article
                10.1056/NEJMra1705454
                29791828
                48319402-a727-46a9-a25c-d3563deedbd2
                History

                Comments

                Comment on this article