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      Use of Animal Models in Understanding Cancer-induced Bone Pain.

      Cancer Growth and Metastasis
      Libertas Academica, Ltd.
      metastatic bone disease, inflammation, cytokines, NGF, ASIC, oxidative stress, syngeneic tumor model

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          Abstract

          Many common cancers have a propensity to metastasize to bone. Although malignancies often go undetected in their native tissues, bone metastases produce excruciating pain that severely compromises patient quality of life. Cancer-induced bone pain (CIBP) is poorly managed with existing medications, and its multifaceted etiology remains to be fully elucidated. Novel analgesic targets arise as more is learned about this complex and distinct pain state. Over the past two decades, multiple animal models have been developed to study CIBP's unique pathology and identify therapeutic targets. Here, we review animal models of CIBP and the mechanistic insights gained as these models evolve. Findings from immunocompromised and immunocompetent host systems are discussed separately to highlight the effect of model choice on outcome. Gaining an understanding of the unique neuromolecular profile of cancer pain through the use of appropriate animal models will aid in the development of more effective therapeutics for CIBP.

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          Author and article information

          Journal
          26339191
          4552039
          10.4137/CGM.S21215

          metastatic bone disease,inflammation,cytokines,NGF,ASIC,oxidative stress,syngeneic tumor model

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