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      The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages

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          Abstract

          <p class="first" id="d175682e368">The independent emergence late in 2020 of the B.1.1.7, B.1.351 and P.1 lineages of SARS-CoV-2 prompted renewed concerns about the evolutionary capacity of this virus to overcome public health interventions and rising population immunity. Here, by examining patterns of synonymous and non-synonymous mutations that have accumulated in SARS-CoV-2 genomes since the pandemic began, we find that the emergence of these three “501Y lineages” coincided with a major global shift in the selective forces acting on various SARS-CoV-2 genes. Following their emergence, the adaptive evolution of 501Y lineage viruses has involved repeated selectively favoured convergent mutations at 35 genome sites: mutations we refer to as the 501Y meta-signature. The ongoing convergence of viruses in many other lineages on this meta-signature suggests that it includes multiple mutation combinations capable of promoting the persistence of diverse SARS-CoV-2 lineages in the face of mounting host immune recognition. </p><p class="first" id="d175682e371">An analysis of synonymous and non-synonymous mutations in SARS-CoV-2 genomes since the inception of the COVID-19 pandemic provides insights into the emergence of a convergent mutational signature in the 501Y lineage (alpha, beta and gamma variants) that is also likely present in other lineages that impacts host immune recognition. </p>

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          September 2021
          September 2021
          Article
          10.1016/j.cell.2021.09.003
          86b2fcfb-13f4-4b4b-b47b-aa275559c000
          © 2021

          https://www.elsevier.com/tdm/userlicense/1.0/

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