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      Levodopa effects on [ (11)C]raclopride binding in the resting human brain.

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          Abstract

          Synaptic dopamine (DA) release induced by amphetamine or other experimental manipulations can displace [ (11)C]raclopride (RAC*) from dopamine D2-like receptors. We hypothesized that exogenous levodopa might increase dopamine release at striatal synapses under some conditions but not others, allowing a more naturalistic assessment of presynaptic dopaminergic function. Presynaptic dopaminergic abnormalities have been reported in Tourette syndrome (TS).

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          Most cited references54

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          Neural Responses during Anticipation of a Primary Taste Reward

          Neuron, 33(5), 815-826
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            The Yale-Brown Obsessive Compulsive Scale

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              Expectation and dopamine release: mechanism of the placebo effect in Parkinson's disease.

              The power of placebos has long been recognized for improving numerous medical conditions such as Parkinson's disease (PD). Little is known, however, about the mechanism underlying the placebo effect. Using the ability of endogenous dopamine to compete for [11C]raclopride binding as measured by positron emission tomography, we provide in vivo evidence for substantial release of endogenous dopamine in the striatum of PD patients in response to placebo. Our findings indicate that the placebo effect in PD is powerful and is mediated through activation of the damaged nigrostriatal dopamine system.
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                Author and article information

                Journal
                F1000Res
                F1000Research
                F1000 Research, Ltd.
                2046-1402
                2015
                : 4
                Affiliations
                [1 ] Departments of Psychiatry, Neurology, Radiology, and Anatomy & Neurobiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
                [2 ] School of Arts and Sciences, Washington University, St. Louis, MO, 63130, USA ; Temple University, Philadelphia, PA, USA.
                [3 ] Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
                [4 ] School of Arts and Sciences, Washington University, St. Louis, MO, 63130, USA ; Department of Ophthalmology, University of Cincinnati, Cincinnati, OH, USA.
                [5 ] Departments of Psychiatry & Behavioral Sciences, and Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
                [6 ] Departments of Radiology, Psychiatry, Bioengineering, and Anatomy & Neurobiology, Washington University, St. Louis, MO, 63130, USA ; Avid Radiopharmaceuticals, Philadelphia, PA, USA.
                Article
                10.12688/f1000research.5672.1
                4490799
                26180632
                6fa8a06d-9647-479b-bdfb-7b8db5cd949d
                History

                D2,PET,Tourette,accumbens,dopamine,emission,levodopa,midbrain,nigra,nucleus,positron,raclopride,receptor,substantia,syndrome,tomography

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