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      Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging

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      Nature Reviews Neuroscience

      Springer Nature

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          Abstract

          The majority of functional neuroscience studies have focused on the brain's response to a task or stimulus. However, the brain is very active even in the absence of explicit input or output. In this Article we review recent studies examining spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal of functional magnetic resonance imaging as a potentially important and revealing manifestation of spontaneous neuronal activity. Although several challenges remain, these studies have provided insight into the intrinsic functional architecture of the brain, variability in behaviour and potential physiological correlates of neurological and psychiatric disease.

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          Journal
          Nature Reviews Neuroscience
          Nat Rev Neurosci
          Springer Nature
          1471-003X
          1471-0048
          September 2007
          September 2007
          : 8
          : 9
          : 700-711
          10.1038/nrn2201
          17704812
          © 2007
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