Blog
About

  • Record: found
  • Abstract: found
  • Article: not found
Is Open Access

OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices.

Read this article at

ScienceOpenPublisherPMC
Bookmark
      There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

      Abstract

      To compare the quality of four OCT-angiography(OCT-A) modules.

      Related collections

      Most cited references 26

      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Split-spectrum amplitude-decorrelation angiography with optical coherence tomography

      Amplitude decorrelation measurement is sensitive to transverse flow and immune to phase noise in comparison to Doppler and other phase-based approaches. However, the high axial resolution of OCT makes it very sensitive to the pulsatile bulk motion noise in the axial direction. To overcome this limitation, we developed split-spectrum amplitude-decorrelation angiography (SSADA) to improve the signal-to-noise ratio (SNR) of flow detection. The full OCT spectrum was split into several narrower bands. Inter-B-scan decorrelation was computed using the spectral bands separately and then averaged. The SSADA algorithm was tested on in vivo images of the human macula and optic nerve head. It significantly improved both SNR for flow detection and connectivity of microvascular network when compared to other amplitude-decorrelation algorithms.
        Bookmark
        • Record: found
        • Abstract: found
        • Article: not found

        IMAGE ARTIFACTS IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

        To describe image artifacts of optical coherence tomography (OCT) angiography and their underlying causative mechanisms. To establish a common vocabulary for the artifacts observed.
          Bookmark
          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          A Computational Tool for Quantitative Analysis of Vascular Networks

          Angiogenesis is the generation of mature vascular networks from pre-existing vessels. Angiogenesis is crucial during the organism' development, for wound healing and for the female reproductive cycle. Several murine experimental systems are well suited for studying developmental and pathological angiogenesis. They include the embryonic hindbrain, the post-natal retina and allantois explants. In these systems vascular networks are visualised by appropriate staining procedures followed by microscopical analysis. Nevertheless, quantitative assessment of angiogenesis is hampered by the lack of readily available, standardized metrics and software analysis tools. Non-automated protocols are being used widely and they are, in general, time - and labour intensive, prone to human error and do not permit computation of complex spatial metrics. We have developed a light-weight, user friendly software, AngioTool, which allows for quick, hands-off and reproducible quantification of vascular networks in microscopic images. AngioTool computes several morphological and spatial parameters including the area covered by a vascular network, the number of vessels, vessel length, vascular density and lacunarity. In addition, AngioTool calculates the so-called “branching index” (branch points / unit area), providing a measurement of the sprouting activity of a specimen of interest. We have validated AngioTool using images of embryonic murine hindbrains, post-natal retinas and allantois explants. AngioTool is open source and can be downloaded free of charge.
            Bookmark

            Author and article information

            Affiliations
            [1 ] Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Switzerland.
            [2 ] Bern Photographic Reading Center, University of Bern, Switzerland.
            [3 ] Department of Clinical Research, Inselspital Bern University Hospital, University of Bern, Switzerland.
            [4 ] Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
            Journal
            PLoS ONE
            PloS one
            Public Library of Science (PLoS)
            1932-6203
            1932-6203
            2017
            : 12
            : 5
            28489918
            10.1371/journal.pone.0177059
            PONE-D-17-10099
            5425250

            Comments

            Comment on this article

            Similar articles 1,245

            Cited by 14

            Most referenced authors 216