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      LncRNAs: Bridging environmental sensing and gene expression.

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          Abstract

          The survival of all organisms is dependent on complex, coordinated responses to environmental cues. Non-coding RNAs have been identified as major players in regulation of gene expression, with recent evidence supporting roles for long non-coding (lnc)RNAs in both transcriptional and post-transcriptional control. Evidence from our laboratory shows that lncRNAs have the ability to form hybridized structures called R-loops with specific DNA target sequences in S. cerevisiae, thereby modulating gene expression. In this Point of View, we provide an overview of the nature of lncRNA-mediated control of gene expression in the context of our studies using the GAL gene cluster as a model for controlling the timing of transcription.

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          Author and article information

          Journal
          RNA Biol
          RNA biology
          Informa UK Limited
          1555-8584
          1547-6286
          December 2016
          : 13
          : 12
          Affiliations
          [1 ] a Department of Biochemistry , Purdue University , West Lafayette , IN , USA.
          [2 ] b Purdue University Center for Cancer Research, Purdue University , West Lafayette , IN , USA.
          Article
          10.1080/15476286.2016.1240139
          5207385
          27700226

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