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      P2Y12 and P2Y13 receptors involved in ADPβs induced the release of IL-1β, IL-6 and TNF-α from cultured dorsal horn microglia.

      Journal of Pain Research
      Dove Medical Press Ltd.
      p38 mitogen-activated protein kinase, NF-kB, P2 receptor, glial activation

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          Abstract

          P2 receptors have been implicated in the release of neurotransmitter and pro-inflammatory cytokines due to their response to neuroexcitatory substances in the microglia. Dorsal horn P2Y12 and P2Y13 receptors are involved in the development of pain behavior induced by peripheral nerve injury. However, it is not known whether P2Y12 and P2Y13 receptors activation is associated with the expression and the release of interleukin-1B (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) in cultured dorsal spinal cord microglia. For this reason, we examined the effects of ADPβs (ADP analog) on the expression and the release of IL-1β, IL-6, and TNF-α.

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          Journal
          28794655
          5536317
          10.2147/JPR.S137131

          p38 mitogen-activated protein kinase,NF-kB,P2 receptor,glial activation

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