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      Comparison of effects of anti-angiogenic agents in the zebrafish efficacy-toxicity model for translational anti-angiogenic drug discovery.

      Drug Design, Development and Therapy
      Informa UK Ltd.
      angiogenesis, zebrafish toxicity assay, therapeutic window, VEGFR inhibitors

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          Abstract

          Anti-angiogenic therapy in certain cancers has been associated with improved control of tumor growth and metastasis. Development of anti-angiogenic agents has, however, been saddled with higher attrition rate due to suboptimal efficacy, narrow therapeutic windows, or development of organ-specific toxicities. The aim of this study was to evaluate the translational ability of the zebrafish efficacy-toxicity model to stratify anti-angiogenic agents based on efficacy, therapeutic windows, and off-target effects to streamline the compound selection process in anti-angiogenic discovery.

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          Author and article information

          Journal
          25170251
          4145829
          10.2147/DDDT.S55621

          angiogenesis,zebrafish toxicity assay,therapeutic window,VEGFR inhibitors

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