23
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Engineering yeast metabolism for production of terpenoids for use as perfume ingredients, pharmaceuticals and biofuels

      , ,
      FEMS Yeast Research
      Oxford University Press (OUP)

      Read this article at

      ScienceOpenPublisher
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Terpenoids represent a large class of natural products with significant commercial applications. These chemicals are currently mainly obtained through extraction from plants and microbes or through chemical synthesis. However, these sources often face challenges of unsustainability and low productivity. In order to address these issues, Escherichia coli and yeast have been metabolic engineered to produce non-native terpenoids. With recent reports of engineering yeast metabolism to produce several terpenoids at high yields, it has become possible to establish commercial yeast production of terpenoids that find applications as perfume ingredients, pharmaceuticals and advanced biofuels. In this review, we describe the strategies to rewire the yeast pathway for terpenoid biosynthesis. Recent advances will be discussed together with challenges and perspectives of yeast as a cell factory to produce different terpenoids.

          Related collections

          Author and article information

          Journal
          FEMS Yeast Research
          Oxford University Press (OUP)
          1567-1364
          October 31 2017
          December 01 2017
          December 2017
          October 31 2017
          December 01 2017
          December 2017
          : 17
          : 8
          Article
          10.1093/femsyr/fox080
          a7604ee6-89e0-467c-a4e1-0b1fea6455f0
          © 2017
          History

          Social policy & Welfare,Medicine,Biochemistry,Ecology,Environmental studies,Life sciences

          Comments

          Comment on this article