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      Mitochondria targeting by environmental stressors: Implications for redox cellular signaling.

      1 , 2

      Toxicology

      Elsevier BV

      Arsenic, Heavy metals, Mitochondria, ROS, Redox signaling

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          Abstract

          Mitochondria are cellular powerhouses as well as metabolic and signaling hubs regulating diverse cellular functions, from basic physiology to phenotypic fate determination. It is widely accepted that reactive oxygen species (ROS) generated in mitochondria participate in the regulation of cellular signaling, and that some mitochondria chronically operate at a high ROS baseline. However, it is not completely understood how mitochondria adapt to persistently high ROS states and to environmental stressors that disturb the redox balance. Here we will review some of the current concepts regarding how mitochondria resist oxidative damage, how they are replaced when excessive oxidative damage compromises function, and the effect of environmental toxicants (i.e. heavy metals) on the regulation of mitochondrial ROS (mtROS) production and subsequent impact.

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          Author and article information

          Journal
          Toxicology
          Toxicology
          Elsevier BV
          1879-3185
          0300-483X
          November 01 2017
          : 391
          Affiliations
          [1 ] Departments of Medicine and Pathology, University of Illinois College of Medicine at Chicago, IL, USA.
          [2 ] Departments of Medicine and Pathology, University of Illinois College of Medicine at Chicago, IL, USA. Electronic address: mbonini@uic.edu.
          Article
          S0300-483X(17)30202-0 NIHMS964527
          10.1016/j.tox.2017.07.013
          5939563
          28750850

          Arsenic, Heavy metals, Mitochondria, ROS, Redox signaling

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