Quercetin induces cell cycle arrest and apoptosis in CD133(+) cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin.

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Abstract

The colorectal cancer stem cells (CSCs) with the CD133(+) phenotype are a rare fraction of cancer cells with the ability of self-renewal, unlimited proliferation and resistance to treatment. Quercetin has anticancer effects with the advantage of exhibiting low side effects. Therefore, we evaluated the anticancer effects of quercetin and doxorubicin (Dox) in HT29 cancer cells and its isolated CD133(+) CSCs.

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Most cited references 27

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Chemotherapy resistance of glioblastoma stem cells.

A Eramo, L. Ricci-Vitiani, A Zeuner … (2006)

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Multitargeted cancer prevention by quercetin.

Akira Murakami, Hitoshi Ashida, Junji Terao (2008)

Quercetin is an anti-oxidative flavonoid widely distributed in the plant kingdom. Phenolic hydroxyl groups at the B-ring and the 3-position are responsible for its free radical-scavenging activity. Quercetin is commonly present as a glycoside and is converted to glucuronide/sulfate conjugates during intestinal absorption and only conjugated metabolites are therefore found in circulating blood. Although metabolic conversion attenuates its biological effects, active aglycone may be generated from the glucuronide conjugates by enhanced beta-glucuronidase activity during inflammation. With respect to its relationship with molecular targets relevant to cancer prevention, quercetin aglycone has been shown to interact with some receptors, particularly an aryl hydrocarbon receptor, which is involved in the development of cancers induced by certain chemicals. Quercetin aglycone has also been shown to modulate several signal transduction pathways involving MEK/ERK and Nrf2/keap1, which are associated with the processes of inflammation and carcinogenesis. Rodent studies have demonstrated that dietary administration of this flavonol prevents chemically induced carcinogenesis, especially in the colon, whilst epidemiological studies have indicated that an intake of quercetin may be associated with the prevention of lung cancer. Dietary quercetin is, therefore, a promising agent for cancer prevention and further research is warranted.

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Cancer stem cells in solid tumors.

Laurie E. Ailles, Irving L Weissman (2007)

Cancer stem cells (CSCs) are cells that drive tumorigenesis, as well as giving rise to a large population of differentiated progeny that make up the bulk of the tumor, but that lack tumorigenic potential. CSCs have been identified in a variety of human tumors, as assayed by their ability to initiate tumor growth in immunocompromised mice. Further characterization studies have demonstrated that gene expression profiles in breast cancer correlate with patient prognosis, and brain CSCs are specifically resistant to radiation through DNA damage repair. In addition, specific signaling pathways play a functional role in CSC self renewal and/or differentiation, and early studies indicate that CSCs are associated with a microenvironmental niche. Thus the biological properties of CSCs are just beginning to be revealed, and the continuation of these studies should lead to the development of CSC-targeted therapies for cancer treatment.

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Author and article information

Journal

Journal ID (iso-abbrev): Iran J Basic Med Sci

Title: Iranian journal of basic medical sciences

Publisher:

ISSN: 2008-3866

ISSN (Print): 2008-3866

Publication date (Electronic): Jul 2015

Volume: 18

Issue: 7

Affiliations

[1 ] Molecular Research Lab, Department of Pharmacology and Toxicology, Tehran University of Medical Sciences, Tehran, Iran.

[2 ] Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.

[3 ] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Article

PMC ID: 4556754

PubMed ID: 26351552

SO-VID: 44c0b7f2-c9c9-467a-bcae-9afb095fa352

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Keywords: Apoptosis,Cancer stem cells,Cell cycle,Doxorubicin,Drug resistance,Quercetin

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Keywords: Apoptosis, Cancer stem cells, Cell cycle, Doxorubicin, Drug resistance, Quercetin

Quercetin induces cell cycle arrest and apoptosis in CD133(+) cancer stem cells of human colorectal HT29 cancer cell line and enhances anticancer effects of doxorubicin.

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Abstract

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Stress signalling in stem cells

Most cited references 27

Chemotherapy resistance of glioblastoma stem cells.

Multitargeted cancer prevention by quercetin.

Cancer stem cells in solid tumors.

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