Blog
About

32
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production

      , , , ,

      Chinese Journal of Natural Medicines

      Elsevier BV

      Read this article at

      ScienceOpenPublisher
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Four new triterpene saponins, mandshunosides F-I ( 1–4 ), together with five known compounds ( 5–9 ), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products. Bisdesmosidic saponin ( 3–9 ) showed modest suppression of NO production with the inhibition ratios in the range of 51.3%–64.6% at 50 μmol·L –1 , whereas monodesmosidic saponins with a free carboxyl group at C-28 ( 1 and 2 ) showed potent inhibitory activities with IC 50 values being 12.7 and 8.3 μmol·L –1 , respectively.

          Related collections

          Author and article information

          Journal
          Chinese Journal of Natural Medicines
          Chinese Journal of Natural Medicines
          Elsevier BV
          18755364
          February 2018
          February 2018
          : 16
          : 2
          : 131-138
          Article
          10.1016/S1875-5364(18)30039-6
          © 2018

          Comments

          Comment on this article