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Four new triterpene saponins, mandshunosides F-I ( 1–4 ), together with five known
compounds ( 5–9 ), were isolated from the roots and rhizomes of Clematis mandshurica.
Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis
products. Bisdesmosidic saponin ( 3–9 ) showed modest suppression of NO production
with the inhibition ratios in the range of 51.3%–64.6% at 50 μmol·L –1 , whereas monodesmosidic
saponins with a free carboxyl group at C-28 ( 1 and 2 ) showed potent inhibitory
activities with IC 50 values being 12.7 and 8.3 μmol·L –1 , respectively.