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      Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

      Proceedings of the National Academy of Sciences of the United States of America
      Animals, Colonic Neoplasms, drug therapy, Doxorubicin, administration & dosage, pharmacokinetics, therapeutic use, Drug Carriers, Drug Stability, Epirubicin, Female, Gallium Radioisotopes, diagnostic use, Liposomes, Lymphoma, Mice, Mice, Inbred BALB C, Mice, Inbred ICR, Tissue Distribution

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          Abstract

          The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect is substantially greater than that observed previously with conventional liposomes and is associated with a more than 5-fold prolongation of liposome circulation time in blood, a marked decrease in uptake by tissues such as liver and spleen, and a corresponding increased accumulation in implanted tumors. These and other properties described here have expanded considerably the prospects of liposomes as an effective carrier system for a variety of pharmacologically active macromolecules.

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