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      Obesity as a risk and severity factor in rheumatic diseases (autoimmune chronic inflammatory diseases).

      Frontiers in Immunology
      Frontiers Media S.A.
      inflammation, obesity, body mass index, rheumatoid arthritis, adipokines, rheumatic diseases

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          Abstract

          The growing body of evidence recognizing the adipose tissue (AT) as an active endocrine organ secreting bioactive mediators involved in metabolic and inflammatory disorders, together with the global epidemic of overweight and obesity, rise obesity as a hot topic of current research. The chronic state of low-grade inflammation present in the obese condition and the multiple pleiotropic effects of adipokines on the immune system has been implicated in the pathogenesis of several inflammatory conditions including rheumatic autoimmune and inflammatory diseases. We will discuss the main relevant evidences on the role of the AT on immune and inflammatory networks and the more recent evidences regarding the effects of obesity on the incidence and outcomes of the major autoimmune chronic inflammatory diseases.

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          Author and article information

          Journal
          25426122
          4227519
          10.3389/fimmu.2014.00576

          inflammation,obesity,body mass index,rheumatoid arthritis,adipokines,rheumatic diseases

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