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      Call for Papers: Green Renal Replacement Therapy: Caring for the Environment

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      About Blood Purification: 3.0 Impact Factor I 5.6 CiteScore I 0.83 Scimago Journal & Country Rank (SJR)

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      TRPV1-mediated diuresis and natriuresis induced by hypertonic saline perfusion of the renal pelvis.

      Author(s): 1 , ,
      Publication date (Electronic):
      Journal: American journal of nephrology
      Publisher: S. Karger AG

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          Abstract

          The transient receptor potential vanilloid type 1 (TRPV1) channel is known to be activated by multiple stimuli, albeit its role in mediating renal function is largely unknown. This study was designed to test the hypothesis that TRPV1 mediates diuresis and natriuresis induced by hypertonic saline perfusion into the pelvis.

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          OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity.

          R Strotmann, C. Harteneck, K Nunnenmacher … (2000)
          Ca2+-permeable channels that are involved in the responses of mammalian cells to changes in extracellular osmolarity have not been characterized at the molecular level. Here we identify a new TRP (transient receptor potential)-like channel protein, OTRPC4, that is expressed at high levels in the kidney, liver and heart. OTRPC4 forms Ca2+-permeable, nonselective cation channels that exhibit spontaneous activity in isotonic media and are rapidly activated by decreases in, and are inhibited by increases in, extracellular osmolarity. Changes in osmolarity of as little as 10% result in significant changes in intracellular Ca2+ concentration. We propose that OTRPC4 is a candidate for a molecular sensor that confers osmosensitivity on mammalian cells.
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            The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli

            Makoto Tominaga, Michael Caterina, Annika B. Malmberg … (1998)
            Article 0 comments Cited 193 times – based on 0 reviews     Review now
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              TRP channels: an overview.

              Stine Falsig Pedersen, Grzegorz Owsianik, Bernd Nilius (2015)
              The TRP ("transient receptor potential") family of ion channels now comprises more than 30 cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the basis of sequence homology, the TRP family can be divided in seven main subfamilies: the TRPC ('Canonical') family, the TRPV ('Vanilloid') family, the TRPM ('Melastatin') family, the TRPP ('Polycystin') family, the TRPML ('Mucolipin') family, the TRPA ('Ankyrin') family, and the TRPN ('NOMPC') family. The cloning and characterization of members of this cation channel family has exploded during recent years, leading to a plethora of data on the roles of TRPs in a variety of tissues and species, including mammals, insects, and yeast. The present review summarizes the most pertinent recent evidence regarding the structural and functional properties of TRP channels, focusing on the regulation and physiology of mammalian TRPs.
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                Author and article information

                Journal
                Journal ID (iso-abbrev): Am. J. Nephrol.
                Title: American journal of nephrology
                Publisher: S. Karger AG
                ISSN (Electronic): 1421-9670
                ISSN (Print): 0250-8095
                Publication date (Electronic): 2007
                Volume: 27
                Issue: 5
                Affiliations
                [1 ] Department of Medicine, Michigan State University, East Lansing, Mich. 48823, USA.
                Article
                Publisher Item ID: 000107665
                DOI: 10.1159/000107665
                PubMed ID: 17717412
                SO-VID: cabfdec6-69ac-4d61-b06f-23daf29758a1
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