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      Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression.

      Nature medicine
      Disease Progression, Homeostasis, Humans, Neoplasms, physiopathology

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          Abstract

          Tumors are like new organs and are made of multiple cell types and components. The tumor competes with the normal microenvironment to overcome antitumorigenic pressures. Before that battle is won, the tumor may exist within the organ unnoticed by the host, referred to as 'occult cancer'. We review how normal tissue homeostasis and architecture inhibit progression of cancer and how changes in the microenvironment can shift the balance of these signals to the procancerous state. We also include a discussion of how this information is being tailored for clinical use.

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          Author and article information

          Journal
          21383745
          3569482
          10.1038/nm.2328

          Chemistry
          Disease Progression,Homeostasis,Humans,Neoplasms,physiopathology
          Chemistry
          Disease Progression, Homeostasis, Humans, Neoplasms, physiopathology

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