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      Calcinosis and Metastatic Calcification due to Vitamin D Intoxication

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      Hormone Research

      S. Karger AG

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          Abstract

          Vitamin D, a fat-soluble vitamin, can be associated with significant morbidity when prescribed in large doses. We describe a hypoparathyroid patient with vitamin D intoxication who developed painful periarticular calcinosis, nephrocalcinosis with hypertension and chronic renal failure in addition to band keratopathy and hearing loss. He was treated with combination therapy including prednisone, phosphate-binding antacid, phenytoin and disodium etidronate. After 20 months of follow-up there was a significant reduction of periarticular calcinosis, but no improvement in renal function, band keratopathy or hearing loss and possible calcification of the ossicles. The clinicopathologic features of metastatic calcification and the various treatment modalities are reviewed.

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          Author and article information

          Journal
          Hormone Research
          Horm Res
          S. Karger AG
          1423-0046
          0301-0163
          1992
          1992
          : 37
          : 1-2
          : 68-77
          Article
          10.1159/000182285
          © 1992
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