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Abstract
Vitamin D, a fat-soluble vitamin, can be associated with significant morbidity when
prescribed in large doses. We describe a hypoparathyroid patient with vitamin D intoxication
who developed painful periarticular calcinosis, nephrocalcinosis with hypertension
and chronic renal failure in addition to band keratopathy and hearing loss. He was
treated with combination therapy including prednisone, phosphate-binding antacid,
phenytoin and disodium etidronate. After 20 months of follow-up there was a significant
reduction of periarticular calcinosis, but no improvement in renal function, band
keratopathy or hearing loss and possible calcification of the ossicles. The clinicopathologic
features of metastatic calcification and the various treatment modalities are reviewed.