48
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

      Cell
      Animals, Bile Acids and Salts, biosynthesis, blood, toxicity, Biological Transport, physiology, Cholesterol 7-alpha-Hydroxylase, metabolism, Cholesterol, Dietary, DNA-Binding Proteins, genetics, Female, Gene Expression, Homeostasis, drug effects, Liver, pathology, Male, Mice, Mice, Knockout, RNA, Messenger, analysis, Receptors, Cytoplasmic and Nuclear, Transcription Factors, Triglycerides

      Read this article at

      ScienceOpenPubMed
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were outwardly identical to wild-type littermates. FXR/BAR null mice were distinguished from wild-type mice by elevated serum bile acid, cholesterol, and triglycerides, increased hepatic cholesterol and triglycerides, and a proatherogenic serum lipoprotein profile. FXR/BAR null mice also had reduced bile acid pools and reduced fecal bile acid excretion due to decreased expression of the major hepatic canalicular bile acid transport protein. Bile acid repression and induction of cholesterol 7alpha-hydroxylase and the ileal bile acid binding protein, respectively, did not occur in FXR/BAR null mice, establishing the regulatory role of FXR/BAR for the expression of these genes in vivo. These data demonstrate that FXR/BAR is critical for bile acid and lipid homeostasis by virtue of its role as an intracellular bile acid sensor.

          Related collections

          Author and article information

          Comments

          Comment on this article