The Use of XRPD and ATR-FTIR in the Screening of Three Component Co-amorphous Systems Created via a Melt-Quench Method

Summary

Multiple three-component co-amorphous systems have been created via a melt-quench method. This has been confirmed by a single glass transition in the individual DSC traces and then reinforced by X-ray diffraction data, which show an absence of crystalline material.

ATR-FTIR has also been used to show a change in bonding vibrations between the physical mixtures and co-amorphous samples. The change in bonding vibrations indicates different molecular interactions within the co-amorphous materials.