3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Intravenous augmentation treatment and lung density in severe α1 antitrypsin deficiency (RAPID): a randomised, double-blind, placebo-controlled trial.

      Read this article at

      ScienceOpenPublisherPubMed
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The efficacy of α1 proteinase inhibitor (A1PI) augmentation treatment for α1 antitrypsin deficiency has not been substantiated by a randomised, placebo-controlled trial. CT-measured lung density is a more sensitive measure of disease progression in α1 antitrypsin deficiency emphysema than spirometry is, so we aimed to assess the efficacy of augmentation treatment with this measure.

          Related collections

          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          1474-547X
          0140-6736
          Jul 25 2015
          : 386
          : 9991
          Affiliations
          [1 ] Asthma and Airway Centre, University Health Network, Toronto Western Hospital, and Division of Respiratory Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address: kchapman@ca.inter.net.
          [2 ] St Vincent's Hospital, Fitzroy, Melbourne, VIC, Australia.
          [3 ] Skåne University Hospital, Lund University, Malmö, Sweden.
          [4 ] National Jewish Health, Denver, CO, USA.
          [5 ] Gentofte Hospital, Hellerup, Denmark.
          [6 ] University of Texas Health Science Center at Tyler, Tyler, TX, USA.
          [7 ] Division of Image Processing, Radiology, Leiden University Medical Center, Leiden, Netherlands.
          [8 ] CSL Behring, King Of Prussia, PA, USA.
          [9 ] Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland.
          Article
          S0140-6736(15)60860-1
          10.1016/S0140-6736(15)60860-1
          26026936

          Comments

          Comment on this article