Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients

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Abstract

SARS-CoV-2 proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. 11 of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day one after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of IgG and IgA.

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Journal

Title: Clinical Infectious Diseases

Publisher: Oxford University Press (OUP)

ISSN (Print): 1058-4838

ISSN (Electronic): 1537-6591

Publication date Created: May 20 2021

Publication date (Electronic): May 20 2021

Affiliations

[1 ]Department of Pathology, Brigham and Women’s Hospital, Boston, MA, USA

[2 ]Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA

[3 ]Harvard Medical School, Boston, MA, USA

[4 ]Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, MA, USA

[5 ]Division of Infectious Diseases, Centre Hospitalier de l’Université de Montréal, Montreal, QC, Canada

[6 ]Center for Clinical Investigation, Brigham and Women’s Hospital, Boston, MA, USA

Article

DOI: 10.1093/cid/ciab465

SO-VID: f0cb261d-a231-405e-89e5-ae220b4d1cc2

License:

https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model

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