Saposhnikoviae divaricata : a phytochemical, pharmacological, and pharmacokinetic review

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Saposhnikoviae divaricata (Turcz.) Schischk (SD) is a traditional Chinese herb commonly used to treat clinical conditions such as rheumatism and allergic rhinitis. This review article evaluates a collection of works on in vitro and biochemical studies of SD. The discourse on the diverse class of chromones and coumarins in SD offers an insight to the pharmacological effects of these bioactive constituents as anti-inflammatory, analgesic, immunoregulatory, antioxidative, and anti-proliferative agents. It is highlighted that there is a structural relationship between the constituents and bioactive activities, which in effect provides a valid reasoning and reaffirm the use of SD in the treatment of the pathologies in Chinese medicine.

Most cited references 34

Record: found
Abstract: not found
Article: not found

The pathogenesis of rheumatoid arthritis.

Iain B McInnes, Georg Schett (2012)

0 comments Cited 325 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: outside-in signaling and relationship to tumor progression.

Brigitte Bauvois (2012)

This review focuses on matrix metalloproteinases (MMPs)-2 (gelatinase A) and -9 (gelatinase B), both of which are cancer-associated, secreted, zinc-dependent endopeptidases. Gelatinases cleave many different targets (extracellular matrix, cytokines, growth factors, chemokines and cytokine/growth factor receptors) that in turn regulate key signaling pathways in cell growth, migration, invasion, inflammation and angiogenesis. Interactions with cell surface integral membrane proteins (CD44, αVβ/αβ1/αβ2 integrins and Ku protein) can occur through the gelatinases' active site or hemopexin-like C-terminal domain. This review evaluates the recent literature on the non-enzymatic, signal transduction roles of surface-bound gelatinases and their subsequent effects on cell survival, migration and angiogenesis. Gelatinases have long been drug targets. The current status of gelatinase inhibitors as anticancer agents and their failure in the clinic is discussed in light of these new data on the gelatinases' roles as cell surface transducers - data that may lead to the design and development of novel, gelatinase-targeting inhibitors. Copyright © 2011 Elsevier B.V. All rights reserved.

0 comments Cited 139 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Coumarins: old compounds with novel promising therapeutic perspectives.

R. Vazquez Gomez, N. De Groot, Maria E Riveiro … (2009)

Natural as well as synthetic coumarins have recently drawn much attention due to its broad pharmacological activities. Many coumarins and their derivatives exert anti-coagulant, anti-tumor, anti-viral, anti-inflammatory and anti-oxidant effects, as well as anti-microbial and enzyme inhibition properties. The recognition of key structural features within coumarin family is crucial for the design and development of new analogues with improved activity and for the characterization of their mechanism of action and potential side effects. The different substituents in the coumarin nucleus strongly influence the biological activity of the resulting derivatives. Although some coumarins have been already characterized to evoke a particular biological activity, the challenge would be the design and synthesis of new derivatives with high specific activity for other pharmacological targets and define their mechanism of action to achieve new therapeutic drugs. The present review highlights the current progress in the development of coumarin scaffolds for drug discovery as novel anti-cancer agents. The major challenges about coumarins include the translation of current knowledge into new potential lead compounds and the repositioning of known compounds for the treatment of cancer.

0 comments Cited 47 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (publisher-id): CJNM

Title: Chinese Journal of Natural Medicines

Publisher: Elsevier

ISSN (Electronic): 1875-5364

Publication date (Electronic): 20 April 2017

Volume: 15

Issue: 4

Pages: 255-264

Affiliations

[1] ¹School of Health and Biomedical Sciences, RMIT University, Victoria 3001, Australia

[2] ²School of Science, RMIT University, Victoria 3001, Australia

Author notes

*Corresponding author: Angela Wei Hong Yang, Tel: 61-3-9925-7175, Fax: 61-3-9925-7178, E-mail: angela.yang@ 123456rmit.edu.au

All the authors have no conflicts of interest to declare.

Article

Publisher ID: S1875-5364(17)30042-0

DOI: 10.1016/S1875-5364(17)30042-0

SO-VID: ee141b28-5131-4e06-bb69-e1b38e1b7aad

History

Date received : 20 June 2016

ScienceOpen disciplines: Medicine,Pharmaceutical chemistry,Pharmacology & Pharmaceutical medicine,Complementary & Alternative medicine

Keywords: Anti-inflammatory,Immunomodulatory,Anti-proliferative, Saposhnikoviae divaricata ,Chinese herbal medicine,Analgesic

Data availability:

ScienceOpen disciplines: Medicine, Pharmaceutical chemistry, Pharmacology & Pharmaceutical medicine, Complementary & Alternative medicine

Keywords: Anti-inflammatory, Immunomodulatory, Anti-proliferative, Saposhnikoviae divaricata , Chinese herbal medicine, Analgesic

Saposhnikoviae divaricata: a phytochemical, pharmacological, and pharmacokinetic review

Read this article at

Abstract

Most cited references 34

The pathogenesis of rheumatoid arthritis.

New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: outside-in signaling and relationship to tumor progression.

Coumarins: old compounds with novel promising therapeutic perspectives.

Author and article information

Journal

Affiliations

Author notes

Article

History

Comments

Comment on this article

Similar content 224

Cited by 30

Most referenced authors 410